According to the World Health Organization, Cardiovascular diseases are the leading cause of death in the world nowadays. Over the years, numerous approaches have been tried in the attempt to detect and prevent them, resulting in the selection of physiological risk factors responsible for generating these pathologies. Among the various detectors, aortic stiffness is considered one of the most accurate indicators for preventing the development of diseases related to the cardiovascular system. It is currently assessed by measuring Pulse Wave Velocity (PWV) in the carotid-femoral segment and, over the years, efforts have been made to calculate this variable as simply and, above all, non-invasively as possible.