Compression ratio and boost pressure increment represent an effective solution to enhance performances and thermal efficiency of turbocharged spark-ignition internal combustion engines (ICEs). Nonetheless, the higher in-cylinder pressure and temperature may favor the onset of knocking phenomena, thus limiting the achievable potential improvements. The high number of engine operating parameters on which it is possible to act make experimental campaigns extremely time and capital intensive. Therefore, numerical simulations could represent a valuable solution for analyzing the combustion process, thus predicting knock occurrence by reducing the number of experimental tests and lead time. In this context, the aim of this activity is to develop a 3D-CFD numerical model able to predict the occurrence, location and onset of knock in a high-performance turbocharged gasoline direct injection (GDI) spark-ignition engine, with a limited computational time required differently from other approaches available in literature.