Giulia Rubini
On the application of PINNs to Mathematical Biology problems: a comparative study.
Rel. Luigi Preziosi, Nikolaos Sfakianakis. Politecnico di Torino, Corso di laurea magistrale in Ingegneria Matematica, 2026
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Abstract
Physics-Informed Neural Networks (PINNs) have emerged as a promising meshless framework for solving partial differential equations, embedding physical laws directly into the training process of neural networks. Their potential applicability to mathematical biology is particularly appealing, as many biological phenomena are governed by complex, nonlinear PDEs defined on irregular domains where classical discretisation methods can be costly or cumbersome. This thesis investigates the capabilities and limitations of PINNs when applied to biological equations, with a focus on systems that exhibit spatial pattern formation. Following a thorough theoretical treatment of the PINN framework, including loss formulation, network architecture, training dynamics, and known failure modes, two case studies of increasing complexity are examined.
First, the one-dimensional Burgers equation is solved using a standard PINN, yielding accurate results that validate the methodology as a reliable solver for well-posed, low-dimensional nonlinear problems
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