Chronic skin ulcers affect about 2% of the global population and represent a major clinical and economic challenge for healthcare systems worldwide. Their management entails prolonged treatments, frequent hospital visits, and high costs, while patients often experience pain, reduced mobility, and psychological distress. Infection further worsens these outcomes, leading to serious complications such as localized tissue necrosis, osteomyelitis, necrotizing fasciitis, sepsis, and septic shock. When untreated, infections can transform a chronic wound into a life-threatening systemic condition, highlighting the urgent need for early detection and timely intervention. Although clinical, microbiological, and imaging-based methods allow pathogen identification and functional assessment, they often suffer from limitations in invasiveness, accessibility, cost, or processing time.