Climate change poses severe threats to human populations worldwide, with particularly strong impacts on health. Extreme events are becoming more frequent, intense, and prolonged as a consequence of global warming. Among these, heat waves represent one of the most direct manifestations, with significant health implications. This thesis focuses on the Mediterranean basin, identified as a ’climate change hotspot’ due to its warming rates higher than other zones, and high population density. An ensemble of nine climate models from the Coupled Model Intercomparison Project Phase 6 (CMIP6) was employed to assess future temperature trends under two Shared Socioeconomic Pathways (SSP2-4.5 and SSP5-8.5) and three time horizons (short: 2021-2040, medium: 2041-2060, long: 2081-2100), and compared with the historical baseline (1981-2010).