Public perception of aviation is a key driver of demand for enhanced environmental sustaina-bility, with the aim of mitigating the industry's effects on climate change. The Flightpath 2050 initiative reflects this perception by aiming for environmental neutrality, global leadership, and societal responsiveness. Achieving these objectives requires a shift in the approach used to the design aeronautical systems, particularly concerning the integration of manufacturing and supply chain processes. The systems for system approach (S4S) aims to interconnect these systems from the conceptual design phase, enhancing integration and efficiency while mini-mizing costs and time losses. The objective of this thesis is to propose a methodology that leverages concepts derived from Model-Based Systems Engineering (MBSE) and Product Line Engineering (PLE) to generate all possible S4S architectures variants.