Skin cancer represents the most prevalent form of malignancy worldwide, primarily categorized into cutaneous carcinomas—basal cell carcinoma and squamous cell carcinoma—and melanomas. Among the treatments for cutaneous carcinoma, radiotherapy is considered an effective option, particularly kilovolt radiotherapy. Superficial kV-based radiotherapy uses low-energy X-rays, depositing most energy in the first few millimeters of tissue. This makes it suitable for treating superficial lesions, minimizing damage to underlying tissues and enhancing treatment precision. Angiographic optical coherence tomography (OCTA) is employed to monitor treatment response. This non-invasive technique enables volumetric rendering of the tissue's vascular network without contrast agents. OCTA provides insights into tissue morphology and vascular structure, with an imaging depth of up to 1 mm, facilitating detailed visualization of epidermal and dermal microstructures.