The active response of cells to mechanical stimuli has been a subject of extensive research over the past two decades. Initially, the focus was on cells cultured on flat substrates and subjected to periodic stretching. Several theoretical models were proposed to account for various physical factors influencing cellular response. However, in the last decade, there has been growing interest in how geometrical cues, such as substrate curvature, affect cell behavior. This interest is driven by experimental findings that highlight the importance of curvature in cell mechanical response due to the interplay between cellular contractility and substrate geometry. Research has shown that cells respond to mechanical influences, not just chemical signals.