Temperature measurement is nowadays of fundamental importance for both monitoring and controlling most natural and industrial processes. Thus, it is crucial to have the capabilities to measure temperature in different environments, including the most difficult ones. As an example, industrial lyophilization requires reliable temperature monitoring under harsh conditions. Lyophilization, also known as freeze drying, is the process that is used to remove water from biological and/or pharmaceutical products in order to improve their shelf-life while preserving as much as possible the original characteristics. It takes place inside an isolated stainless steel containers at low pressure and low temperature in three different phases.