Fibrinogen (FB) is a protein that plays a crucial role in lots of processes in the organism, in particular for what concerns the interaction between implants and tissues, through the formation of a substratum which is essential for adhesion and aggregation of cells and/or platelets (clotting). This process may lead to the full integration of the implant or to chronic inflammation which determines the subsequent implant failure. During biomaterial implantation, several steps occur including, first of all, protein adsorption which strongly depends on surface features such as wettability, charge, topography and roughness. Proteins (such as fibrinogen) may assume various orientations and may adsorb in variable amount and, as a consequence, may undergo different structure variations, eventually denaturing, i.e.