The development of living organisms is driven by the orchestrated expression of proteins and hormones which allow cell differentiation and thus organ formation. In plants, this role is mainly driven by the hormone auxin, which is produced at the single-cell level and actively transported across tissues, i.e., by the action of dedicated carriers. Among the carriers, PINs are known to mediate the outgoing flux of auxin and display polarization patterns across tissues. PIN polarity and therefore auxin transport is determined by the expression level of a protein kinase called Pinoid, encoded in the gene PID which is the neighbouring gene of APOLO, a long non-coding RNA presumably leading to changes in local epigenetic status.