Lorena Bevilacqua
Crystal engineering: a novel strategy for the resolution of chiral compounds.
Rel. Elena Simone. Politecnico di Torino, Corso di laurea magistrale in Ingegneria Chimica E Dei Processi Sostenibili, 2022
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Abstract
The chemical industry often deals with chiral molecules, also called enantiomers. These are two molecules with the same chemical formula but that are mirror-like due to the different orientation of some functional groups. Enantiomers of the same molecule are often indicated with D and L or with R and S. Both enantiomers of the same molecule have the same physical-chemistry properties, but they might differ in pharmacological active and bioavailability. In fact, one enantiomer might provide the desired effect while the other might be ineffective or, even worse, toxic. For this reason, chirality is an important issue in the pharmaceutical industry, where enantiomers of Active Pharmaceutical Ingredients (APIs) need to be carefully differentiated and separated.
To overcome this challenge, crystallization comes might be a suitable selective separation strategy
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