Label-free biosensors for the study of cell biology have finally come of age. Recent developments have transformed biosensors from low throughput, high maintenance research tools to high throughput, low maintenance screening platforms. In parallel, biosensors have evolved from analytical tools designed exclusively for the analysis of molecular interactions to powerful platforms for the study of cell biology at the whole-cell level. Despite these successes, however, bioelectronics has not yet succeeded in developing a widely applicable all-electronics biosensor platform. This is partly because in the most promising CMOS-based capacitive biosensors, DC or low-frequency signals cannot be used to probe beyond the electrical double layer formed by shielding salt ions, which means that under physiological conditions the sensing of a target analyte is located even at a short distance from the sensor (∼1 nm) is severely hampered.