This work is originated by the need to better investigate the human factors in the context of safety in rotorcraft aviation. In particular, the aim is to describe, along with the typical helicopter aerial work missions, the state of the art of the safety in order to outline the picture of the potential hazardous situations and the related safety standards. Great attention is paid to the perspective which allows to better understand the allocation of responsibilities within organizations, underlining the importance of organizational management in harmful occurrences. Subsequently, the objective is to provide to the reader essential information about the mission analysis methodologies, suggesting a case analysis process developed on the basis of human-factors-oriented theories and taxonomies.