Local hemodynamics plays a major role in promoting atherosclerosis development in arteries. Despite low/oscillatory wall shear stress (WSS) is widely recognized as marker of deranged hemodynamic, recent evidences suggested its weak ability to predict plaque localization and endothelial disfunction at the early stage. In this contest, a marked interest recently emerged on the topological skeleton (TS) of WSS vector field. The WSS TS consists in: WSS fixed points, where the WSS vanishes, and WSS manifolds, identifying WSS contraction/expansion regions at the luminal surface, linking fixed points. WSS TS features allow the identification of biomechanical events linked to “aggravating” biological events. Among aggravating biological events, mass transport processes are markedly involved by mediating, e.g., the lipids accumulation at the arterial wall.