Waqas Khan
Automated Type 2 Brugada Syndrome Classification from 12-Lead ECGs: A Dual-Stream Deep Learning and Random Forest Ensemble.
Rel. Mario Roberto Casu, Vincenzo Randazzo, Eros Gian Alessandro Pasero. Politecnico di Torino, Corso di laurea magistrale in Ingegneria Elettronica (Electronic Engineering), 2026
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Abstract
Type 2 Brugada Syndrome (T2-BrS) is the most prevalent Brugada ECG phenotype in the general population, yet its characteristic saddleback morphology is not independently diagnostic without pharmacological provocation and specialist interpretation. No published end-to-end automated pipeline targets the binary T2-BrS versus Non-BrS classification task directly from standard 12-lead recordings. This thesis addresses that gap. A labelled dataset of 362 patient-disjoint 12-lead ECG recordings (188 confirmed Type 2 BrS and 174 Non-BrS) was assembled through two acquisition pathways: semi-automated digitisation of approximately 1,000 paper ECGs from a Sardinian Brugada patient registry using the ECGD software tool, and direct extraction of digital signals from GE MAC2000 XML archives.
Following S-peak-centred windowing and resampling to 500 Hz, a 44-dimensional clinical feature vector was constructed for each recording, encoding five published diagnostic criteria: the de Luna α/β r′-wave angular measurements, the Corrado ST curvature index, the Crea inferior-lead ST depression sign, the Babai-Bigi aVR criterion, and the Ishida repolarisation markers (Tpeak–Tend interval and r-J interval)
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