The progressive development of the New Space Economy is leading to the so called In-Space Manufacturing (ISM) initiatives, supported by both space agency and private companies. ISM capabilities represent the opportunity to reshape the strategic and economic foundations of the emerging in-space economy. The dependency of orbital manufacturing systems on Earth-based resupply mission remains one of the critical challenges to be addressed, with significant environmental, economic, and logistical impacts and implications. This thesis, developed in collaboration with Thales Alenia Space Italia, within the EFESTO research context, has firstly been oriented toward investigating how sustainability has been addressed within the space sector and ISM missions through a Systematic Literature Review (SLR).