This thesis focuses on the study of vehicle passengers comfort (driver and left rear passenger), and in particular the response of the human-seat subsystem to vibrations from the road. The work began with the analysis of a complete vehicle model on a mod of MSC AdamsCar software, called MB-SHARC developed by Stellantis. Numerical simulation results obtained through this software were compared with experimental data provided by the Balocco Proving Ground. The proposed tests to study the vibrational response of the system are of three types: obstacle, comfort track and high speed track. Also the signal analysis was carried out through a software developed in Stellantis named VDArco.