Andrada Silisteanu
Seeing beyond the surface: Quantifying Actinic Keratosis Progression with OCT and OCTA.
Rel. Kristen Mariko Meiburger, Giulia Rotunno, Mengyang Liu. Politecnico di Torino, Corso di laurea magistrale in Ingegneria Biomedica, 2024
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Abstract
Actinic keratosis, a precancerous skin lesion, can transform into squamous cell carcinoma if left untreated, passing through critical stages such as Bowen's disease. Diagnosis of actinic keratosis can be made clinically, by visually analyzing the shape and size of the lesion, or dermoscopically, by investigating the more superficial layer of the skin. However, since these are qualitative analyses, limited by the inability to explore the deeper layers of the skin, they cannot distinguish an actinic keratosis from a tumor. This is why biopsy, an invasive procedure that ensures certain diagnosis of cancerous and non-cancerous condition, is often used. What if it were possible to diagnose actinic keratosis and follow its evolution without invasive intervention? This thesis project proposes an alternative: it explores the use of OCT (optical coherence tomography) and OCTA (OCT angiography), non-invasive imaging techniques that, by exploiting light and the principle of interference, can capture high-resolution images and volumes of biological tissues structure and vasculature.
The aim is to demonstrate how these techniques, already used in medical settings, can support the qualitative and quantitative distinction between actinic keratosis and its possible developmental stages
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