In the current context of actions needed to counter climate change, the continuous tightening of CO₂ and criteria pollutant emissions limits is considered to be a pivotal challenge to the mobility sector. Different potential technological solutions are being explored to face this scenario. The vast research area ranges from the implementation of electrification in powertrains, also considering exclusively electrified ones, to the continuous development of the internal combustion engine (ICE) hardware. Focusing on the latter, among the technological solutions investigated, different fuel typologies are currently under examination to substitute fossil-derived fuels. In this environment, hydrogen is recognized to be particularly interesting, thanks to its combustion properties: high flame propagation speed and wide flammability range, which allow lean combustion, and good knock resistance.