Matteo Di Paoloemilio
Characterizing Hexanematic Turbulence in a Coarse-Grained Cellular Model of Confluent Epithelia.
Rel. Alessandro Pelizzola. Politecnico di Torino, Corso di laurea magistrale in Physics Of Complex Systems (Fisica Dei Sistemi Complessi), 2026
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Abstract
The scientific goal of the proposed project is to elucidate how cellular morphology influences collective motion in living matter. This thesis combines a bottom-up cell-resolved approach to tissue modeling, based on the Cellular Potts Model (CPM), with a top-down hydrodynamic framework recently introduced in the literature by Giomi and collaborators. Specifically, we focused on the characterization of fully developed active turbulence in confluent epithelial tissues. We started from an implementation of the CPM that introduces cellular activity via a positive feedback mechanism inspired by the cytoskeletal activity driving the cellular motion in keratocytes. This model was known to have an activity-induced flocking transition, corresponding to the onset of multiscale hexanematic order.
This suggested that the emergent properties of the chaotic collective motion could be captured, to a certain extent, by the hydrodynamic equations of hexanematic liquid crystals
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