Electrochemical sensors convert chemical information into electrical signals, allowing biomolecules to be detected even in complex samples. Nanostructured metal oxides with spinel structures are especially useful due to their high catalytic activity, large surface area, and enhanced electron transfer, which improve sensor sensitivity and selectivity. In this study, europium-based spinel oxide nanoparticles doped with copper, cobalt, and zinc (CuEu₂O₄, CoEu₂O₄, ZnEu₂O₄) were prepared using an autocombustion method in order to exploit the electronic properties of europium which thanks to its f-orbital configuration should facilitate electron exchange. The morphological and crystal structures of the nanoparticles were investigated: Field Emission Scanning Electron Microscope (FESEM) analysis confirmed that the particles were uniform and well dispersed, while X-ray diffraction (XRD) demonstrated the formation of a highly crystalline cubic spinel structure.