Nuclear science and technology have prompted remarkable advancements in medicine, electricity production, and other essential industries. However, like many other human endeavors, such activities generate hazardous by-products, particularly, nuclear waste. Due to its relatively long isolation period which ranges from a hundred to thousands of years, nuclear waste poses a challenging issue to tackle. In Italy, a National Repository for very low- and low-level nuclear waste is to be developed by SOGIN; as such, establishing a facility to be operated and controlled for about 350 years. This thesis aims to address the repository not only as a technical infrastructure, but also as a layer of memory subject to reinterpretation over time, through utilizing time as design tool and embracing entropy as an inevitable condition.