One of the most debated topics in recent years is the greenhouse effect caused by fossil fuels combustion, with consequent carbon dioxide emissions into the atmosphere. It is now undoubted that this effect is a threat to the entire biosphere, including humans. To overcome this challenge, a transition to cleaner energy technologies is needed. One promising technology is photocatalysis, which allows the direct conversion of solar energy to chemical energy in the form of hydrogen, which can then be stored. In this framework, the present study proposes a preliminary techno-economic analysis of an industrial plant for photocatalytic hydrogen production via water splitting.