The burden of cancer affects millions of people worldwide every year. Bone cancer, in particular, is characterized by aggressive growth and great suffering for the patients. Conventional therapies, such as surgery, chemotherapy, or radiotherapy, may cause significant side effects and part of cancerous tissue might not be completely removed, causing recurrence. Moreover, surgical removal of bone cancer can leave critical bone defects, requiring the use of a bone graft. Recently, hyperthermia has emerged as a possible alternative. This therapy takes advantage of the higher sensitivity to heat of cancer cells to destroy them by locally increasing the temperature in the range 41-45 °C, causing molecular and cellular alterations which end up in cell death.