Today, the increasing elderly population means a greater susceptibility to musculoskeletal disorders, typically managed, if they persist, through arthroplasty. These bone-contact titanium implants, despite their useful mechanical and physicochemical properties, remain susceptible to various complications, the most important of which are loosening and infection. Among these failures, prosthetic joint infection is the most significant, and the responsible bacterial species include Gram-positive and Gram-negative microorganisms. These infections often require prolonged treatment with broad-spectrum antibiotics, potentially exacerbating the critical problem of antibiotic resistance. This phenomenon not only increases treatment costs but also leads to higher levels of morbidity and mortality. There are several explanations for the increase in this problem, such as the growing global consumption of antibiotics, often without appropriate prescriptions, and the use of antibiotics in non-human settings.