In recent years, cell culture electronic interfaces have become increasingly valuable for studying neuronal behaviour. However, research in electrochemistry is constrained by the high cost of existing instrumentation. This work addresses these limitations, helping neuroscientists explore new ways to slow neuronal degeneration and develop new therapies for neurodegenerative diseases. This thesis aims to design an ultra-low-cost, low-noise, high-gain electronic device for acquiring neural signals, particularly amperometric ones. Amperometry, an electrochemical technique, applies a static potential to an electrode to drive a redox reaction in the target analyte, producing a current proportional to its concentration. This project is a collaboration with two departments at the University of Turin: Drug Science and Technology and Physics.