Enrico Castorina
Optimized design and biological validation of a mechanical stretching device to induce cardiac hypertrophy in engineered heart tissues.
Rel. Valeria Chiono, Irene Carmagnola, Mattia Spedicati, Thomas Eschenhagen. Politecnico di Torino, Corso di laurea magistrale in Ingegneria Biomedica, 2024
Abstract
Cardiovascular diseases (CVD) are the leading cause of death worldwide, accounting for over 17 million death each year. Environmental and genetic factors contribute to a dramatic increase in the number of people affected by such conditions in the coming years. The study of these diseases is of fundamental importance for developing appropriate treatments. These conditions are primarily treated using surgical approaches, pharmacological approaches, or often by combining both. To develop effective pharmacological treatments that maximize therapeutic action, it is necessary to study these diseases; this process is known as drug screening. The drug screening process involves various stages to ensure that the drug can be marketed and that it has an actual therapeutic effect.
After the identification of the potential clinical actions of the drugs, these are tested on models that may be in vitro or in vivo, before proceeding to clinical and preclinical development, which allows for evaluations of safety and efficacy in humans
Relatori
Anno Accademico
Tipo di pubblicazione
Numero di pagine
Informazioni aggiuntive
Corso di laurea
Classe di laurea
Ente in cotutela
Aziende collaboratrici
URI
![]() |
Modifica (riservato agli operatori) |
