Multiple Sclerosis (MS) is a chronic demyelinating autoimmune disease that affects the central nervous system (CNS) causing a wide spectrum of signs and symptoms: motor symptoms such as spasticity and weakness, fatigue, dysphonia, speech or vocal disorders. Hypophonia, which is characterized by a reduction in the intensity of the voice, has a particular relevance among all the signs of the disease which demands for vocal analysis and therapies that allow to reduce social life limitations of MS patients. One of the most advanced hospital facilities that is involved in the MS research is the therapy and rehabilitation department of Don Carlo Gnocchi Foundation in Milan.