Nickel-based alloys are commonly used in demanding applications such as aerospace, nuclear, oil and gas production. The production of components made of these materials is often highly complicated because of their high melting temperature, low castability and forgeability. This condition makes Additive Manufacturing (AM) so attractive for these alloys. Nevertheless, the defectiveness and the microstructure of additively manufactured components differ from traditional ones. Hot Isostatic Pressing (HIP) for these materials is often compulsory and reported in international standards because of the stringent safety levels typically adopted. Nonetheless, the standards still refer to traditional cast or wrought microstructure and adapt poorly to the AM materials, and this is where the thesis finds its focal point.