The thesis project aims to explore new possible applications of smart solutions in packaging to enhance the excellence of Made in Italy, with a focus on the fashion sector, through the application of the systemic approach. This thesis project is part of the project "Future e-pack" launched by MICS - Made in Italy Circolare e Sostenibile, which goal is to enhance the role of packaging as a mediator between user and company, to convey information about the sustainability of the product contained through the application of digital solutions. Based on this guideline, the thesis project analyzes the Italian fashion system in order to identify possible applications of smart packaging that can remedy the critical issues that emerged from this analysis.