The advancement of drug delivery techniques has been crucial in enhancing drug efficacy, patient comfort, and safety. While various routes such as oral, parenteral, and transdermal drug delivery have been explored, each presents unique advantages and challenges. This thesis focuses on transdermal drug delivery (TDD) and, specifically, the use of microneedle (MN) technology to overcome the limitations posed by the skin barrier. MNs provide a non-invasive, pain-free method for delivering drugs across the skin layers, offering improved bioavailability and controlled dosage delivery. All five main types of MNs—solid, coated, hollow, hydrogel, and dissolvable— have their respective advantages and limitations in drug delivery applications.