Over the years, enforcement and continuous improvement of seismic regulations have been evidenced worldwide. In Italy, after major seismic events such as the Molise and L’Aquila earthquakes, the seismic design was implemented, and it became mandatory from July 1st, 2009 with NTC2008 code. Addressing seismic assessment in existing strategic structures, built before the 60’s, is becoming increasingly necessary and evident since the seismic risk that characterizes this type of structures is very high. Within this framework, this paper focuses on the seismic retrofitting of the most vulnerable building of “Ospedale Edoardo Agnelli,” a hospital complex located in Torino, Italy. The retrofitting strategy consists of a damping tower system, whose prime is to increase the structural performance, minimize occupant disruption and indirect costs, guarantee the immediate operation of the building even during high-intensity earthquakes, and elongate the building's structural service life.