The heart is a vital organ responsible for pumping blood full of oxygen in all the tissues and districts of the body. The cardiac cycle is made up of the alternation of two phases: systole (contraction) and diastole (relaxation). A healthy heart is crucial for the general well-being and heart diseases are the first cause of death in Western countries. Among the most common cardiovascular diseases is heart failure, an impairment in the blood pumping function that prevents the delivery of a sufficient cardiac output. There are more types of heart failure, one of which is the systolic failure, characterized by a reduced ejection fraction (EF) and arises when the left ventricle (LV) loses the ability to contract properly.