Spinal cord injuries (SCI) are a devastating neurological and pathological condition that often results in severe motor, sensory and autonomic impairments. Its pathophysiology includes acute and chronic phases that begin immediately after the injury and continue for days, or even weeks, after the event. Many treatments have been developed to prevent neurodegenerative processes, reduce secondary neuronal damage, and improve neuronal recovery. Despite the different degrees of success achieved in the past few decades, there is currently no effective therapy for SCI. The complexity of SCI and the numerous biochemical and physiological changes in the damaged spinal cord are primarily responsible for this gradual but slow improvement.