Precision medicine and personalized care have emerged as essential approaches to effectively preventing and treating chronic pathologies. In this context, implantable drug delivery devices have assumed a central role, enabling customized drug administration. Moreover, they address the widespread problem of non-compliance with treatment, enhance drug bioavailability, allow the use of lower dosages, and minimize side effects by keeping drug concentration within the therapeutic window, which decreases the development of drug resistance. To achieve controlled drug delivery, numerous actively controlled stimuli approaches have been used. Among them, ultrasound, magnetic field, and electrical field have been the most popular. However, these devices often rely on impractical continuous external stimuli.