In the expansive realm of neuroscience, continual progress in unraveling the intricacies of the brain’s mechanisms stands as an indispensable foundation for addressing the complexities inherent in neurodegenerative disorders. Conditions such as Parkinson’s disease and Alzheimer’s present profound inquiries into our understanding of both normal and pathological brain physiology. Neurodegenerative diseases are characterized by the progressive degeneration of the structure and function of the nervous system; these conditions primarily affect neurons and then lead to a range of cognitive, motor, and behavioral symptoms. In order to evaluate the properties of neuron’s electrical activity in in vitro culture, the availability of devices able to combine low noise and high gain features, interfaced with advanced micro-electrode arrays is needed.