This master’s thesis presents a comprehensive study on the deblending of hydrogen within the natural gas transmission network, with a specific focus on the Southern Sicily region. The research investigates the behavior of a gas mixture originating from North Africa, composed of natural gas and green hydrogen in different concentrations, considering a 5%, 10%, and 20% blend. The gas network was modeled using data from the National Transmission System Operator and GIS tools, with topology analysis performed with MATLAB for simulation purposes. The simulations include an examination of the gas mixture’s behavior throughout the pipelines, emphasizing the deblending process at the network’s final nodes, corresponding to delivery points.