The growing demand in the satellite market, for a variety of applications (e.g., Earth Observation, Science, Communication, Navigation), is driving the space industry towards a new and more efficient approach for their design, assembly, integration and test. Sets of space missions, even with different scopes and objectives, can be identified such to be carried out by satellites sharing the same, basic platform. As a consequence, the resources employed for the development of a satellite can be significantly reduced and mainly focused on the adaptations needed to meet the specific mission and system requirements. However, while adaptations can be easily implemented for some subsystems, for others, like the Thermal Control System, this is not the case as they are highly mission-dependent.