Point-of-Care diagnostic and implantable devices have been on the rise over the last twenty years due to their numerous benefits in healthcare delivery. In this context, nano-graphitic carbon sensors, along with other types of carbon-based sensors, have emerged as optimal candidates, because they can be assembled into densely packed arrays of microelectrochemical sensors with high performance in neurotransmitters detection. The fast-Scan cyclic voltammetry method is one of the best-known methods for measuring electrochemically active neurotransmitters. One of the important aspects of electrochemical measurements is the buffer solution used in the electrochemical sensing of neurotransmitters. However, the effect of the buffer solution has not yet been studied in FSCV measurements.