Ultrasound, long used in a consolidated and widespread way as a diagnostic means, has emerged as a promising therapeutic method for procedures requiring non-invasiveness, target specificity, and temporal efficiency. In recent years, it has been demonstrated that delivering low-intensity focused ultrasound (LIFUS) to nervous tissues can induce inhibitory and/or excitatory effects in the central nervous system (CNS) and peripheral nervous system (PNS). FUS stimulation of the CNS has been widely developed, and several in vivo studies have demonstrated that it can elicit responses in motor and sensory neurons. On the other hand, ultrasonic neuromodulation of the PNS is little explored in vivo, and its mechanisms of action are still uncertain.