Wearable devices are potential power instruments for facing major health-related challenges such as the aging population, chronic diseases, and hospital service delivery. While wearables are nowadays widely used for monitoring physical activity and active life, also through some physiological parameters, their use in the clinical environment remains limited and challenging. Among the many reasons for the limited use of wearable solutions in the clinical field is the lack of a complete and updated regulatory framework, including specific guidelines to establish the accuracy of wearables and the ownership of the cost burden. Not to mention the acceptability of such devices among patients and healthcare providers in terms of comfort and trust.