In the biomedical field, cements are fundamental biomaterials due to their several uses and functions, such as cement pastes used in dentistry or as bone fillers in prosthesis placement.Cements exhibit a viscoelastic-plastic behavior and one of the possible experimental methodologies to investigate their mechanical response is nanoindentation.The obtained experimental data can then be used to fix existing mechanical constitutive models, which could be employed in Finite Element (FE) analyses. Being able to determine a computational mechanical model that best represents the cement’s behavior would open up many avenues in the field of simulations. Depending on the type of material used, different cases of its attitude can be hypothesized.