Self-organization of living system is a fascinating process, interesting not only biologist, but also mathematicians and physicist. In the present work, the attention will focus on the spatial segregation between the primitive endoderm (PrE) and the epiblast (EPI) cells in mammals. The sorting of a mixture of two types of biological cells is already modelled by a modified version of the large-Q Potts model, an energy-based biophysical paradigm that, however, had progressed beyond being merely a proof of concept. Since this approach lacks a physical interpretation, there is a growing interest to develop more detailed dynamic methods to model relevant biophysical processes.