The natural gas network, as well as the road network, the electricity network, and the sewers, represent strategic infrastructures from both an economic and social point of view. Damage to gas pipelines can cause interruption of energy production if the connection with thermal power plants is interrupted. It can affect everyday life, blocking the gas transportation toward homes, schools, hospitals, and any other urban facility. This thesis work focuses on assessing the seismic vulnerability of urban natural gas networks. Pipeline damage produced by ground shaking and permanent ground deformation is calculated through a physical-based methodology. A simulation tool called Pandapipes which is based on the Python programming language was used.