This paper focuses on the details related to Industry 4.0 and safety management. It also discusses how to translate Industry 4.0 content into "Made in China 2025" in the background of Chinas current industrial development. The concept of "Made in China 2025" has received more and more attention from the whole society since it was first proposed in December 2014. This will be the top-level design of Chinas industrial development agenda for the next 10 years. On the difficult road to practice and complete the fourth industrial revolution, this paper generally summarizes the laws of development and historical lessons learned from the routes of the first three industrial revolution processes.