In the past few years, progresses in nanomedicine towards cancer treatment have exhibited that the use of nanoparticles (NPs) can be truly promising, since they have shown to be capable of damaging and killing cancer cells throughout different mechanisms. While various nanomaterials have been de-veloped for this purpose, their use brings with it several potential drawbacks which are still scarcely considered, such as the non-specific uptake of these materials in healthy organs and their potential immunogenicity. This Master Thesis work aims to develop an innovative theranostic immuno-compatible nanoconstruct based on Zinc Oxide nanocrystals (ZnO-NCs), whose properties have revealed huge potential for in vitro and in vivo applications, focusing on one of the most lethal diseases, pancreatic cancer.