Fractures are the most common traumatic injuries associated to large-organs. The development of internal fixation devices such as plates, screws, pins and cerclage wires has led to improved surgical and clinical outcomes. In recent years, shape memory alloy staples have been introduced in orthopedic surgery as alternative fixation devices, with benefits in terms of time of the surgical procedure and improved bone healing. In detail, Nitinol staples dynamically adapt to changes in the bone structure and guarantee the bone-on-bone apposition during the healing process. Further studies are currently conducted to evaluate the staples design and to increase the treatment effectiveness and safety.