Cancer represents one of the main causes of death worldwide, moreover with an increasing occurrence trend. In particular, liver cancer, which frequently affects children too, represents the sixth most common tumor, with still a pretty low relative survival rate despite the research advancements in the last decades. The elective treatment for liver tumors is surgery and a lot of effort has been devoted in finding new intervention techniques that can combine high efficacy with lower patient discomfort. Among them, minimally invasive methods that induce a controlled tissue hyperthermia (radiofrequency, microwave, and laser ablations) have risen great interest because they represent a valid alternative to standard surgical resection, which is not always possible due to the peculiar characteristics of the malignant lesion or the patient general health conditions.