Cardiovascular disease (CVD) is the leading cause of mortality in the world, with about 17.9 million deaths per year corresponding to 32% of total annual deaths. Early diagnosis and treatment of CVD can drastically reduce the chance of premature mortality and guarantee a normal life to the patients. Among the several predictive parameters, arterial stiffness has been proven to be an effective marker for evaluating the cardiovascular risk and it is strongly related with the Pulse Wave Velocity (PWV). Pulse Wave Velocity (PWV) represents the propagation speed of the pressure wave inside the arteries, and it is usually evaluated between the carotid and the femoral sites.